10. Dezember 2015 Evotec receives important pre-clinical milestones as part of its multi-target alliance with Bayer HealthCare

Evotec AG (Frankfurt Stock Exchange: EVT, TecDAX, ISIN: DE0005664809) announced today that its multi-target collaboration with Bayer HealthCare ("Bayer") has reached two important pre-clinical milestones for the transition of two projects from the alliance portfolio into late-stage discovery and pre-clinical development for the treatment of endometriosis. These milestones were achieved under the strategic alliance between Evotec and Bayer entered in October 2012. The goal of this collaboration is to develop three clinical candidates within the five-year alliance. Both parties contribute innovative drug targets and high-quality technology infrastructures and share the responsibility for early research and pre-clinical characterisation of potential clinical candidates in the disease area of endometriosis. Dr Mario Polywka, Chief Operating Officer of Evotec, commented: "Endometriosis is a truly debilitating disease for a large population of women. These milestones represent further good progress in addressing both the underlying inflammation as well as the resulting pain and reflect well on the tremendous combined efforts of both teams of scientists from Evotec and Bayer. We look forward to continuing this productive work and focusing our efforts on bringing forward new drug candidates to tackle this significant disease." Financial details were not disclosed. ABOUT ENDOMETRIOSIS
Endometriosis affects an estimated 176 million women worldwide or 10% of women of reproductive age. It is caused by the abnormal growth of tissue similar to that which lines the uterus (endometrial tissue) in locations outside of the uterine cavity, where it causes ectopic lesion growth and debilitating pain. Endometrial growth is commonly found on the ovaries and pelvic peritoneum, potentially involving other organs of the pelvic cavity as e.g. bladder, bowel, and the rectovaginal space. There is no known cure for endometriosis and most available drug treatments have certain limitations. Endometriosis is a highly complex and heterogeneous disease and there is still a high unmet medical need for innovative therapies which address the individual needs of affected women. The disease can greatly impact a woman's social, professional and personal life, and women with endometriosis often experience a higher incidence of depression and emotional distress due to the uncertainty of diagnosis, unpredictability of symptoms and living a normal life. Find more information at http://endometriosisfoundation.org or http://endometriosis-league.eu/en. Source: www.evotec.com